1. When Rose got trapped in a parallel universe and she was forever separated from the Doctor.
2. And when the Doctor had a chance to give her a proper goodbye, but he was cut off.
3. When the 11th Doctor brought Van Gogh back to the present day to show him his achievements, and it still didn't change the past.
4. When the Weeping Angels sent Billy Shipton back to the '60s and he subsequently met Sally and died on the same day.
5. When the 10th Doctor was regenerating and wasn't ready to let go.
6. When the Doctor thought he survived his fight against the Master and the Time Lords, but Wilfred reminded him of the "he will knock four times" prophecy.
7. When the Master, the only remaining Time Lord, refused to regenerate in the Doctor's hands.
8. When the Doctor broke the laws of time and it still didn't work out for the people he saved.
9. When the Doctor told Reinette to pack a bag and join him, but she never made it into the TARDIS.
10. When John Smith decided to "die" and open the watch, even after he knew what his future with Joan would be like.
11. When Brig was turned into a Cyberman.
12. When Amy spent 30-plus years on Apalapucia, and she convinced Rory to rescue the younger version of herself.
13. When Gallifrey was actually frozen in time and unreachable for the Doctor.
14. When Amy blinked to be reunited with Rory.
15. When the 10th Doctor first met River Song on the day she died even though she knew him for quite a long time.
16. When Rory waited 2,000 years for Amy outside the Pandorica.
17. When Donna's mother told her she was a disappointment after she turned right and altered the future.
18. When the Ninth Doctor sent Rose away because he knew he was going to die.
19. When the 10th Doctor bid farewell to longtime companion Sarah Jane Smith.
20. When Rory got erased from time and then Amy forgot about his entire existence.
21. When Amy committed suicide after realizing she was in a dream.
22. When Clara threw the Doctor's keys into the volcano after he refused to bring Danny Pink back.
23. When Amy discovered her baby was kidnapped after it was too late.
24. When the 11th Doctor shared his first kiss with River Song, but it was her last kiss with him.
25. And when the Doctor wiped Donna's memory because if she remembered anything about her time with him, her mind would explode.
