Buster / Bessie Baxter
Buster would've been great as a girl — she would have inherited her mother's fantastic ginger hair!
Muffy / Duffy Crosswire
Duffy would be quite the dapper, sophisticated heir to the Crosswire empire. Think of him like a young Niles Crane.
Alan / Allison "The Brain" Powers
Let's hear it for Allison, the lady-Brain! Girls can rock academics too!
Fern Walters
Fern would make an adorable bookworm-boy-dog.
Shelley "Binky" Barnes
Technically Binky already has a feminine name, so it's a perfect fit! Curvy girls represent!
Mr. / Ms. Ratburn
Hmmm, Ms. Ratburn somehow looks significantly more comfortable as a female.
Francine / Frankie Frensky
It's easy to forget Francine is a monkey with that hair covering her ears!
Dora Winifred / David Winston "D.W." Read
Isn't it easy to see D.W. being just like your adorably irritating little brother?
Arthur / Anna Read
Arthur's iconic look also looks great on a girl aardvark. How many little girls with glasses would've identified with the character more?