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Eddie Morra (Cooper) is an unemployed writer whose girlfriend Lindy (Cornish) breaks up with him. Eddie believes he has no future, but when a friend introduces him to the experimental drug MDT, Eddie becomes highly focused and highly confident. He is able to recall everything he has read, heard or seen, and he uses the knowledge to become successful in the financial world. Business mogul Carl Van Loon (De Niro) sees Eddie as a potential tool to make money, but Eddie's success also attracts hitmen who pursue him for the MDT. Eddie's stash dwindles, causing him side effects, as he tries to escape being assassinated.