1. The original name for the movie was actually Homeschooled.
2. Lindsay Lohan was originally cast as Regina George, but she was switched to the role of Cady because of her Freaky Friday success.
3. Rachel McAdams and Amanda Seyfried were neck and neck for the role of Regina.
4. A line cut from Kevin G.'s rap was, “It ain’t no trick/ I am this slick / All the ninth-grade ladies / Wanna suck my — WHAT!”
5. The film was almost forced to cut the "wide-set vagina" line.
6. Rajiv Surendra first auditioned for the part of Damian, but then he got called in for Kevin — a part originally written for an Asian person.
7. James Franco was considered for the role of Aaron Samuels.
8. Paramount didn't want Tim Meadows and Amy Poehler in the movie at first.
They were afraid Mean Girls would be perceived as a Saturday Night Live movie.