It holds 200 pipes and is restocked every five days.
It sells Pyrex crack pipes for 25 cents each.
Kailin See, director of the Drug Users Resource Centre, told CTV: "For us, this was about increasing access to safer inhalation supplies in the Downtown Eastside."
Chipped pipes can cause everything from flu, colds and cold sores to HIV.
The initiative has been criticised by the Canadian government.